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Form 8288 for Carlsbad California: What You Should Know
OBJECTIVES: 1. To identify a specific genetic mutation, 2. To assess potential of targeting a specific gene (prostate specific antigen (PSA) gene, G7/beta-catenin signaling (ERGO), E3 ubiquity ligase, PSD30, CD11b and CD38), 3. To evaluate the effectiveness of gene therapy in the progression of prostate cancer after a positive PSA test. METHODS: — Genotypic of 868 human prostate cancer samples (631 men) using PCR amplification of the PSA 18 gene (N = 434 men) revealed a significant association between the PSA 18 gene and 5 different prostate malignancies (including prostate cancer, lung cancer, stomach cancer and liver cancer). (a). Relative risk increase in incidence for PSA 18 gene mutated cells versus PSA gene wild-type cancer cells in prostate cancer patients were observed. (b). PSA 18 gene mutated cells have a 2.3-fold increase in risk of progression from low- to high-grade, 4 times faster tumor progression in PSA 18 gene mutated cells. (c). PSA 18 gene mutant cells were able to grow better in xerography models than PSA 18 + PSA 18 wild-type cells (e). PSA 18 gene mutant cells are resistant to both chemo- and radiotherapy. (f). The relative risk of metastases for PSA 18 tumor cells were decreased by more than 3-fold in immunodeficient mice. (g) The mutation in PSA 18 gene is associated with reduced expression and/or activity of other downstream signaling and survival proteins in tumor tissues after transplantation. — RESULTS: — PSA 18 gene mutant cells were capable of invading and migrating through different types of tissues and organs of mice, such as kidney, liver, lung, pancreas, olfactory bulb, gastrointestinal tract, and blood vessels. — CONCLUSION: We have identified the PSA18 gene mutation as a possible target for cancer treatment, and our results suggest that PSA 18 mutant cells may be a target of cancer treatment. — LOS ONE DOI: 10.1371/journal.pone.
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